â€śStudies have emphasized an antineoplastic effect of the non-psychoactive, phyto-cannabinoid, Cannabidiol (CBD)â€ť, begins the studyâ€™s abstract, which was epublished ahead of print by the National Institute of Health. â€śHowever, the molecular mechanism underlying its antitumor activity is not fully elucidated. Herein, we have examined the effect of CBD on two different human breast cancer cell linesâ€ť.
In both cell lines, â€śCBD inhibited cell survival and induced apoptosis in a dose dependent manner as observed by MTT assay, morphological changes, DNA fragmentation and ELISA apoptosis assay.â€ť
The results â€śsuggest that CBD treatment induces an interplay among PPARÎł, mTOR and cyclin D1 in favor of apoptosis induction in both ER-positive and triple negative breast cancer cells, proposing CBD as a useful treatment for different breast cancer subtypes.â€ť
The full study, conducted by researchers atÂ Alexandria University in Egypt, can be found by clicking here.