HJ: Although CBD interacts with many receptors found in the brain and body (CB1, CB2, 5HT1A, TRPV channels, other G coupled protein receptors etc.), it mainly interacts throughout the brain and body via the Endocannabinoid system. The ECS is a system of receptors found in the brain and body (bones, GI, skin, organs etc.). The ECS is intriguing and important because it is the bodyâ€™s “master regulatory system.” It communicates and interacts with virtually all other bodily systems (CNS, organs, autoimmune system, GI tract etc.) to keep the body in a healthy state, i.e., homeostasis. While research is advancing rapidly, it has already implicated the ECS as a crucial component of health; it is a system that is active, to some extent, in almost all disease states. Since CBD, and cannabis in general, targets this ubiquitous system through various mechanisms of action, cannabis has potential applications for many diseases.
JS: Now that research is moving forward all over the world, we believe that new evidence leading to greater understanding of mechanisms of action will be published almost weekly for the next several decades. This is an exciting time for the discovery of the many benefits of this misunderstood plant. It is also important to note that significant research has already been done on the safety of various cannabinoids, including CBD. Thus far, the safety/toxicity profile for CBD appears to be more in line with everyday foods and vitamins rather than being accompanied by the daunting side effects of many conventional drugs.