As more states legalize marijuana, thereâ€™s growing interest in a cannabis extract â€” cannabidiol, also known asÂ CBD.
Itâ€™s marketed as a compound that can help relieve anxiety â€” and, perhaps, help ease aches and pains,Â too.
Part of the appeal, at least for people who donâ€™t want to get high, is that CBD doesnâ€™t have the same mind-altering effects as marijuana, since it does not contain THC, the psychoactive component of theÂ plant.
â€śMy customers are buying CBD [for] stress relief,â€ť says Richard Ferry, the retail manager of Home Grown Apothecary in Portland, Oregon, where recreational cannabis use is legal under state law, with some restrictions.
Another rationale Ferryâ€™s heard from clients about their CBD use: â€śTheir mother-in-law is in town, and they just want to chillÂ out!â€ť
â€śCBD has gotten a lot of buzz,â€ť Ferry says, as he displays an array of CBD products, including capsules and bottles of liquid CBD oil that users dispense under the tongue with aÂ dropper.
By one estimate, the CBD industry has doubled in size over the last two years, and is now worth $200 million. But with this popularity the hype may have gotten ahead of theÂ science.
â€śThereâ€™s a lot of confusion about how it [CBD] works and what it does exactly,â€ť FerryÂ says.
Researchers now are trying to nail down CBDâ€™sÂ effects.
â€śI think thereâ€™s good evidence to suggest that CBD could be an effective treatment of anxiety and addictionâ€ť and other disorders, says Dr. Esther Blessing, a psychiatrist and researcher at New York University. â€śBut we need clinical trials to findÂ out.â€ť
So far, evidence of the substanceâ€™s anti-anxiety effect comes from animal research and from very small, short-term human studies that suggest CBD exhibits anti-inflammatory and anti-anxiety properties.
These preliminary findings piqued Blessingâ€™s interest. For instance, she points to a 2011 study of a few dozen people, some of whom had social anxiety disorder, who were asked to speak in front of a large audience. Researchers compared anxiety levels in people after they took CBD, compared to those who got the placebo or nothing at all. (The participants didnâ€™t know if theyâ€™d been given the drug or theÂ placebo.)
And what did the scientists find? â€śPeople who took CBD reported significantly less anxietyâ€ť compared to those who got the placebo, Blessing says. â€śItâ€™s reallyÂ interesting.â€ť
Now, with funding from the National Institutes of Health, Blessing and a group of collaborators are about to begin a clinical trial to test whether CBD can help people with post-traumatic stress disorder who also have moderate or severe alcohol useÂ disorder.
During the study, 50 otherwise healthy participants will be given either 400 milligrams of CBD daily, or a placebo. The goal is to see if the participants who take CBD end up drinking less and whether this leads to an improvement in PTSD symptoms. The participants will be given a pharmaceutical-grade CBD, which is more reliable in strength and purity than the supplements that are currently available for sale to theÂ public.
Another Phase 2 clinical trial (to test efficacy and side effects) is exploring whether CBD might help prevent relapse in opioid abusers by reducing craving for the drug. The studyâ€™s led by Yasmin Hurd, a neuroscientist who directs the Addiction Institute at the Mount Sinai School ofÂ Medicine.
Hurd has been trying to rally other top scientists to study CBDâ€™s effects and potential benefits in the treatment of substance abuse.
It may seem counterintuitive that a component of marijuana could be useful in treating addiction to another drug. But Blessing says using CBD is very different from using marijuana. Though CBD is extracted from cannabis, it does not lead to altered perception andÂ cognition.
â€śDrugs can be non-psychoactive and still have an effect on the brain,â€ť Blessing says. â€śCBD does have an effect on the brain, but it seems to affect the brain in possibly medicinal ways.â€ť
Results from Blessing study are a few years off. But in the meantime, just last week, a panel of advisors to the Food and Drug Administration recommended approval of the first pharmaceutical grade CBD, called Epidiolex, to treat severe seizure disorders in children. This could open the door to more research to approve its use in other disorders.
Dr. Robert Carson is a pediatric neurologist at Vanderbilt University who has evaluated the effectiveness of CBD supplements in kids with seizures. He says the supplements can be beneficial for these children. However, he says, if the FDA follows its advisory panelâ€™s advice and approves a pharmaceutical-grade CBD drug, that would open up a new treatment option by delivering a high-quality, consistent dose ofÂ CBD.
â€śOne of the main caveats I tell my patients who use a CBD supplement is that we cannot guarantee whatâ€™s in it,â€ť Carson explains. â€śWe canâ€™t guarantee theÂ consistency.â€ť
Supplements arenâ€™t regulated as strictly as pharmaceuticals, and can vary widely from bottle to bottle or brand toÂ brand.
And thereâ€™s another issue would-be users face: Though CBD supplements are widely available for sale, a legal murkiness surrounds marijuana extracts.
Even if you live in a state where marijuana use is legal, the federal Drug Enforcement Agency still classifies the CBD extract as a Schedule 1 substance â€” the DEAâ€™s most restricted category. According to the agency, â€śSchedule I drugs, substances or chemicals are defined as drugs with no currently accepted medical use and a high potential forÂ abuse.â€ť
Proponents of CBDâ€™s use in treating medical conditions and ailments hope the findings of studies now underway will help change that thinking about its legal classification â€” and its potentialÂ benefits.